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Physiological ovarian aging (NOA) is the gradual loss of ovarian reserve function in older women until they reach menopause while pathological ovarian aging is the premature ovarian failure caused by various pathogenic factors, including decreased ovarian reserve (DOR), ovarian insufficiency (POI) and poor ovarian response (POR) ( in vivo , and in vitro research

Particularly, elevated levels of circulating pro-inflammatory mediators have been found in patients with treatment-refractory depression (TRD), including TNF-, IL-6, IL-1, CRP, and macrophage inflammatory protein-1 (88)

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doi: 10.5114/ceji.2020.103422